Protein Details: Calcium-activated potassium channel slowpoke

Protein ID

ICDB_Pro_0758

Protein Name

Calcium-activated potassium channel slowpoke

Gene Name

slo; CG10693

Organism

Drosophila melanogaster (Fruit fly)

Length

1200 amino acids

AlphaFoldDB

AF-Q03720-F1-model_v4.pdb

Function

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing; phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity; its interaction with both Slob1 and 14-3-3-zeta decreases its activity

Sequence

MASGLIDTNFSSTLANGMSGCDQSTVESLADDPTDSPFDADDCLKVRKYWCFLLSSIFTFLAGLLVVLLWRAFAFVCCRKEPDLGPNDPKQKEQKASRNKQEFEGTFMTEAKDWAGELISGQTTTGRILVVLVFILSIASLIIYFVDASSEEVERCQKWSNNITQQIDLAFNIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNVLKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGDPLDFNNAHRLSYWTCVYFLIVTMSTVGYGDVYCETVLGRTFLVFFLLVGLAMFASSIPEIIELVGSGNKYGGELKREHGKRHIVVCGHITYESVSHFLKDFLHEDREDVDVEVVFLHRKPPDLELEGLFKRHFTTVEFFQGTIMNPIDLQRVKVHEADACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTSPDMQSWTNDYLRGTGMEMYTETLSPTFIGIPFAQATELCFSKLKLLLLAIEIKGAEEGADSKISINPRGAKIQANTQGFFIAQSADEVKRAWFYCKACHEDIKDETLIKKCKCKNLTVQPRSKFDDLDEHHPAPTFTPPELPKRVHVRGSVSGDITRDREDTNLLNRNVRRPNGTGNGTGGMHHMNNTAAAAAAAAAAGKQVNKVKPTVNVSRQVEGQVISPSQYNRPTSRSSGTGTQNQNGGVSLPAGIADDQSKDFDFEKTEMKYDSTGMFHWSPAKSLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSQRGPEFDNLSATAGSPIVLQRRGSVYGANVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTVESLSNRDRCRVGQISLYDGPLAQFGECGKYGDLFVAALKSYGMLCIGLYRFRDTSSSCDASSKRYVITNPPDDFSLLPTDQVFVLMQFDPGLEYKPPAVRAPAGGRGTNTQGSGVGGGGSNKDDNS

PDB Structures

7PXE 7PXF 7PXG 7PXH

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in muscle cells; neurons of the CNS and PNS; mushroom bodies; a limited number of cells in embryonic and larval midgut and in epithelial-derived tracheal cells. During pupariation and embryogenesis; it is expressed in muscles many hours prior to the appearance of functional channels.

DOI ID

10.1126/science.1857984; 10.1016/0896-6273(92)90160-f; 10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1186/gb-2002-3-12-research0080; 10.1523/jneurosci.16-05-01827.1996; 10.1523/jneurosci.15-09-06250.1995; 10.1523/jneurosci.18-07-02360.1998; 10.1016/s0896-6273(00)80995-2; 10.1523/jneurosci.19-10-j0005.1999; 10.1016/s0896-6273(00)80739-4; 10.1073/pnas.081072398; 10.1523/jneurosci.22-10-03855.2002

RefSeq

NP_001014651.1 [Q03720-20]; NP_001014652.1 [Q03720-19]; NP_001014653.1 [Q03720-18]; NP_001014654.1 [Q03720-1]; NP_001014655.1 [Q03720-17]; NP_001014656.1 [Q03720-16]; NP_001014657.1 [Q03720-15]; NP_001014658.1 [Q03720-14]; NP_001014659.1 [Q03720-13]; NP_001014660.1 [Q03720-12]; NP_001014661.2 [Q03720-3]; NP_001014662.1 [Q03720-11]; NP_001014663.1 [Q03720-10]; NP_001014664.1 [Q03720-9]; NP_524486.2 [Q03720-5]; NP_733029.1 [Q03720-7]; NP_996289.1 [Q03720-8]